Phesgo 600 mg/600 mg solution for injection

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Description

How It Works

Phesgo is a fixed-dose combination of pertuzumab and trastuzumab, administered via subcutaneous injection. Pertuzumab and trastuzumab are monoclonal antibodies that target the human epidermal growth factor receptor 2 (HER2). By binding to distinct epitopes on the HER2 receptor, these antibodies block HER2 signaling pathways, inhibit tumor cell proliferation, and mediate antibody-dependent cell-mediated cytotoxicity (ADCC). This combination is used primarily in the treatment of HER2-positive breast cancer, providing a synergistic effect that enhances anti-tumor activity.

List of Side Effects

  • Diarrhea
  • Alopecia (hair loss)
  • Neutropenia (low white blood cell count)
  • Fatigue
  • Nausea
  • Anemia
  • Rash
  • Fever
  • Peripheral neuropathy (numbness or tingling in extremities)
  • Vomiting
  • Cough
  • Cardiotoxicity (heart problems)

List of Indications

  • HER2-positive breast cancer:
    • Early breast cancer (EBC) in combination with chemotherapy as part of a complete treatment regimen for early breast cancer
    • Metastatic breast cancer (MBC) in combination with docetaxel in patients who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease

List of Contraindications

  • Hypersensitivity to pertuzumab, trastuzumab, or any of the excipients
  • Severe dyspnea at rest due to complications of advanced malignancy or requiring supplementary oxygen therapy
  • Pregnancy (due to potential harm to the fetus)

Price in Different Countries

Country Price (USD) Reference Website
United States $6,500 GoodRx
United Kingdom ?5,000 NICE BNF
Canada $8,200 CAD CanadaDrugs.com
Australia $9,000 AUD PBS Australia
India ?450,000 INR 1mg
Pakistan ? 1,000,000 PKR Dawaai.pk

Top 5 Global Brands

  1. Phesgo (Pertuzumab and Trastuzumab) – Roche
  2. Herceptin (Trastuzumab) – Roche
  3. Perjeta (Pertuzumab) – Roche
  4. Kanjinti (Trastuzumab biosimilar) – Amgen
  5. Ogivri (Trastuzumab biosimilar) – Mylan/Biocon
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