Piqray (Alpelisib) 300mg film-coated tablets


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How It Works

Piqray works by inhibiting a protein called phosphatidylinositol 3-kinase (PI3K). PI3K is involved in cell growth, survival, and metabolism. By blocking PI3K, Piqray helps slow down or stop the growth of cancer cells in patients with advanced breast cancer that have a specific genetic mutation known as PIK3CA mutation.

Side Effects

  • Hyperglycemia (high blood sugar)
  • Nausea
  • Fatigue
  • Rash
  • Diarrhea
  • Decreased appetite


  • Piqray is indicated in combination with fulvestrant for the treatment of postmenopausal women, and men, with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA-mutated, advanced or metastatic breast cancer as detected by an FDA-approved test following progression on or after an endocrine-based regimen.

Contra indications

  • Hypersensitivity to alpelisib or any of the excipients
  • Severe hepatic impairment

Price Comparison in Different Countries

Country Price (USD) Reference
United States $12,000.00 GoodRx
United Kingdom ?9,000.00 NHS UK
Australia $15,000.00 AUD Pharmaceutical Benefits Scheme Australia
Canada $13,000.00 CAD MedBroadcast Canada

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