Prasugrel Hydrochloride 5mg (Effient)

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Description

Effient, a formulation of Prasugrel Hydrochloride, is a medication used to prevent blood clots in patients with acute coronary syndrome who are undergoing percutaneous coronary intervention (PCI). Each tablet contains 5mg of Prasugrel, an antiplatelet agent that helps reduce the risk of cardiovascular events such as heart attacks and strokes.

How It Works

Prasugrel Hydrochloride works by inhibiting platelet aggregation. Platelets are small blood cells that clump together to form clots. Prasugrel is a prodrug that, once metabolized in the liver, irreversibly inhibits the P2Y12 ADP-mediated platelet receptor, thereby preventing ADP from binding to its platelet receptor and subsequent platelet activation and aggregation. This action reduces the likelihood of clots forming in arteries, which is critical in preventing heart attacks and other thrombotic cardiovascular events.

Side Effects

  • Bleeding (including gastrointestinal and intracranial bleeding)
  • Hematoma
  • Thrombocytopenia (low platelet count)
  • Hypertension
  • Headache
  • Fatigue
  • Nausea
  • Dizziness
  • Rash
  • Dyspnea (shortness of breath)

Indications

  • Reduction of thrombotic cardiovascular events in patients with acute coronary syndrome (ACS) who are managed with percutaneous coronary intervention (PCI)
  • Patients with unstable angina or non-ST-elevation myocardial infarction (NSTEMI)
  • Patients with ST-elevation myocardial infarction (STEMI) when managed with primary or delayed PCI

Contraindications

  • Active pathological bleeding (e.g., peptic ulcer or intracranial hemorrhage)
  • History of transient ischemic attack (TIA) or stroke
  • Severe hepatic impairment
  • Hypersensitivity to Prasugrel or any component of the product
  • Patients over 75 years of age, unless high risk (e.g., diabetes or history of prior myocardial infarction)
  • Body weight less than 60 kg (dose adjustment needed)

Price in Different Countries

Price Comparison of Effient (Prasugrel Hydrochloride 5mg)
Country Price (USD) Source
United States $300 Drugs.com
Canada $250 CanadaDrugs.com
United Kingdom $270 NHS UK
Australia $280 PBS Australia
India $50 1mg.com

Top 5 Global Brands

  1. Effient (Daiichi Sankyo / Eli Lilly)
  2. Prasita (Dr. Reddy’s Laboratories)
  3. Prasugrel Sandoz (Sandoz)
  4. Efient (AstraZeneca)
  5. Prasugrel Teva (Teva Pharmaceuticals)
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