PROLEUKIN 10 IU 1 FLC

Proleukin 10 IU 1 FLC is a formulation of interleukin-2 (IL-2), a cytokine that plays a crucial role in the immune response. Proleukin is used primarily for its immunostimulatory properties in the treatment of various cancers and immune system disorders.

How It Works

Mechanism of Action

Proleukin (interleukin-2) functions through the following mechanisms:

1. Immune System Activation:
   • Interleukin-2 stimulates the proliferation and activation of T lymphocytes, which are critical components of the immune system. This activation enhances the body’s ability to identify and destroy cancer cells.
2. Cytotoxic T Cell Enhancement:
   • IL-2 promotes the growth and differentiation of cytotoxic T cells, which are responsible for attacking cancerous cells and infected cells.
3. NK Cell Activation:
   • Interleukin-2 also activates natural killer (NK) cells, which play a significant role in the innate immune response by targeting and eliminating cancer cells.
4. Cytokine Production:
   • It increases the production of other cytokines that further amplify the immune response against tumors and infections.

Side Effects

Common Side Effects

• Fever:
  • Elevated body temperature is common and often occurs as part of the body’s immune response.
• Chills:
  • Patients may experience chills or shivering.
• Fatigue:
  • Feelings of tiredness or weakness are frequently reported.
• Nausea and Vomiting:
  • Gastrointestinal discomfort including nausea and occasional vomiting.
• Headache:
  • Headaches are a common complaint during treatment.

Serious Side Effects

• Hypotension:
  • Low blood pressure can occur and may require medical intervention.
• Respiratory Distress:
  • Difficulty in breathing or shortness of breath may arise.
• Renal Impairment:
  • Kidney function may be affected, leading to elevated levels of creatinine or urea.
• Hepatotoxicity:
  • Liver enzyme elevations or liver dysfunction could occur.
• Severe Allergic Reactions:
  • Symptoms like rash, itching, or swelling, particularly in severe cases.

Indications

Proleukin is indicated for:

• Metastatic Melanoma:
  • Treatment of advanced melanoma where other therapies have failed.
• Renal Cell Carcinoma:
  • Used in cases of advanced or metastatic renal cell carcinoma.
• HIV/AIDS:
  • Occasionally used in research settings for its potential role in immune system enhancement in HIV/AIDS patients.
• Other Cancers:
  • It may be used off-label for various other cancers under clinical trials or specific medical recommendations.

Contraindications

Proleukin is contraindicated in:

• Pregnancy:
  • Not recommended during pregnancy due to potential risks to the fetus.
• Severe Renal Impairment:
  • Patients with significant kidney dysfunction should avoid use due to the risk of exacerbating kidney problems.
• Severe Liver Disease:
  • Those with significant liver dysfunction should avoid Proleukin.
• Active Autoimmune Disorders:
  • Patients with active autoimmune diseases may experience exacerbation of symptoms.
• Hypersensitivity:
  • Known hypersensitivity to interleukin-2 or any components of the formulation.

Price in Different Countries

Here is a table showing the approximate prices for Proleukin 10 IU in various countries, along with references:

Country	Price (Per 1 FLC)	Reference
United States	$10,000 – $15,000	GoodRx
United Kingdom	£7,000 – £10,000	NHS UK
Canada	CAD $12,000 – $18,000	Health Canada
Australia	AUD $15,000 – $20,000	PBS Australia
India	₹750,000 – ₹1,000,000	Medlife

Top 5 Global Brands

1. Proleukin – Novartis:
   • The original and most well-known brand of interleukin-2, used for treating certain cancers and enhancing the immune response.
2. Aldesleukin – Teva Pharmaceuticals:
   • A generic version of interleukin-2, providing similar therapeutic benefits for cancer treatment.
3. Rinvoq – AbbVie:
   • Although primarily used for autoimmune conditions, it offers similar immune-modulating effects as Proleukin.
4. Il-2 – Biocon:
   • A brand available in various markets, offering interleukin-2 for cancer treatment.
5. Interleukin-2 – Mylan:
   • Another generic option, providing the same efficacy for managing cancers and immune disorders.