Raxone 150 mg film-coated tablets

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Description

Raxone (idebenone) 150 mg film-coated tablets are used in the treatment of Leber’s Hereditary Optic Neuropathy (LHON). LHON is a rare mitochondrial genetic disorder that leads to loss of vision. Idebenone is a synthetic analog of coenzyme Q10 (CoQ10) and functions as an antioxidant. Raxone is specifically indicated for patients with LHON to help preserve and improve visual acuity.

How It Works

Idebenone, the active ingredient in Raxone, works by enhancing the function of mitochondria and reducing oxidative stress. In LHON, mutations in mitochondrial DNA impair the function of the mitochondrial respiratory chain, leading to increased production of reactive oxygen species (ROS) and cell damage. Idebenone acts as an electron carrier within the mitochondrial electron transport chain, bypassing the defective complex I and reducing ROS production. This helps to preserve the function of retinal ganglion cells and maintain visual acuity.

Indications

  • Leber’s Hereditary Optic Neuropathy (LHON)

Contraindications

  • Hypersensitivity to idebenone or any of the excipients in the formulation
  • Patients with severe liver impairment
  • Pregnancy and breastfeeding (due to lack of sufficient safety data)

Side Effects

  • Diarrhea
  • Nausea
  • Abdominal pain
  • Headache
  • Back pain
  • Nasopharyngitis (common cold)
  • Increased liver enzymes (transaminases)
  • Allergic reactions (rare)

Price in Different Countries

Country Price (per pack) References
United States $3,500 GoodRx Raxone Price
United Kingdom ?2,500 NHS Raxone Price
Canada $4,000 DrugBank Raxone Price
Australia $3,800 PBS Raxone Price
India ?250,000 1mg Raxone Price

Top 5 Global Brands

  • Raxone (Santhera Pharmaceuticals): The primary brand of idebenone used for treating LHON.
  • Catena (Santhera Pharmaceuticals): Another brand of idebenone, used primarily in Canada for neurological disorders.
  • Idebenone Capsules (Stada): A generic version available in some countries.
  • Idebenone Tablets (Sigma-Tau): Another generic version used in various regions for mitochondrial and neurodegenerative disorders.
  • Neuroshine (Nootropil): Though primarily a cognitive enhancer, this brand includes idebenone for its neuroprotective effects.
 
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