Remodulin (Treprostinil Sodium) 10 mg Injection

Remodulin (Treprostinil Sodium) is a synthetic prostacyclin analog used in the treatment of pulmonary arterial hypertension (PAH) and other conditions that involve impaired blood flow. It is administered via continuous intravenous infusion and acts as a potent vasodilator. This medication is designed to improve exercise ability and symptoms in patients with PAH by dilating blood vessels and inhibiting platelet aggregation.

How It Works

Treprostinil, the active ingredient in Remodulin, mimics the effects of prostacyclin, a naturally occurring compound that regulates blood flow and platelet aggregation. It works by:

• Vasodilation: Treprostinil directly relaxes the smooth muscles of blood vessels, leading to their dilation. This results in reduced pulmonary arterial pressure and improved blood flow, alleviating symptoms of PAH.
• Inhibition of Platelet Aggregation: Treprostinil prevents platelets from clumping together, which reduces the risk of blood clots forming in the bloodstream.
• Improved Exercise Capacity: By decreasing the pressure in the pulmonary arteries, Treprostinil can enhance the patient’s exercise capacity and overall quality of life.

Continuous infusion of Treprostinil helps maintain stable drug levels in the bloodstream, ensuring ongoing efficacy in managing PAH.

Side Effects

Common side effects of Remodulin include:

• Headache
• Flushing
• Diarrhea
• Nausea
• Vomiting
• Jaw pain
• Muscle pain
• Skin rash
• Low blood pressure (hypotension)

Serious side effects may include:

• Severe bleeding or bruising
• Severe allergic reactions (e.g., rash, itching, swelling, severe dizziness, trouble breathing)
• Heart palpitations
• Severe hypotension

Patients should seek immediate medical attention if they experience any severe or unusual symptoms.

Indications

Remodulin is indicated for:

• Treatment of pulmonary arterial hypertension (PAH) in patients with functional class II to IV symptoms according to the World Health Organization (WHO) classification.
• Management of PAH to improve exercise ability and delay disease progression.

Contraindications

Remodulin should not be used in patients with:

• Known hypersensitivity to Treprostinil Sodium or any of the excipients in the formulation.
• Severe hepatic impairment: Since the drug is metabolized in the liver, patients with severe liver dysfunction should avoid its use.
• Active bleeding disorders: Due to the risk of exacerbating bleeding problems.
• Pregnancy or breastfeeding: The safety of Remodulin during pregnancy and lactation has not been established. It is advised to avoid use in these conditions unless clearly needed.

Price in Different Countries

Country	Price (per 10 mg Injection)	References
United States	$300 – $500 per vial	GoodRx Remodulin Price
United Kingdom	£220 – £350 per vial	NICE ATOZET Price
Australia	$450 AUD per vial	PBS ATOZET Price
India	₹15,000 – ₹20,000 per vial	1mg Remodulin Price
Canada	$350 – $550 CAD per vial	Pharmacy Checker Remodulin Price

Top 5 Global Brands

Remodulin is a key player in the management of PAH, and the top brands for similar indications and treatments include:

• Tracleer (Bosentan) – Actelion: An endothelin receptor antagonist used for PAH management.
• Revatio (Sildenafil) – Pfizer: A phosphodiesterase-5 inhibitor used to treat PAH.
• Adcirca (Tadalafil) – Eli Lilly: Another phosphodiesterase-5 inhibitor used for PAH treatment.
• Opsumit (Macitentan) – Actelion: An endothelin receptor antagonist used for PAH.
• Ventavis (Iloprost) – Bayer: An inhaled prostacyclin analog for PAH treatment.