Revestive 5 mg powder and solvent for solution for injection

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Description

Revestive (teduglutide) is a medication used to treat short bowel syndrome (SBS) in patients who are dependent on parenteral nutrition. Each vial of Revestive contains 5 mg of teduglutide as a powder, which is reconstituted with a provided solvent before administration as a subcutaneous injection. Teduglutide is an analogue of glucagon-like peptide-2 (GLP-2), a hormone that plays a key role in maintaining the structure and function of the gut.

How It Works

Teduglutide, the active ingredient in Revestive, mimics the effects of the natural hormone GLP-2. GLP-2 enhances intestinal absorption by promoting the growth and repair of the lining of the intestine, increasing blood flow to the gastrointestinal tract, and reducing gastric motility. This helps patients with short bowel syndrome to absorb nutrients more effectively, potentially reducing their dependence on parenteral nutrition.

Indications

  • Treatment of short bowel syndrome (SBS) in adult patients who are dependent on parenteral nutrition
  • Treatment of short bowel syndrome (SBS) in pediatric patients aged 1 year and older who are dependent on parenteral nutrition

Contraindications

  • Known hypersensitivity to teduglutide or any of the excipients
  • Patients with active or suspected malignancy

Side Effects

  • Abdominal pain
  • Nausea
  • Headache
  • Injection site reactions
  • Upper respiratory tract infections
  • Vomiting
  • Fluid overload
  • Cardiac failure

Price in Different Countries

Country Price (per vial) References
United States $9,500 GoodRx Revestive Price
United Kingdom £7,000 NHS Revestive Price
Canada $12,000 Canada Drugs Revestive Price
Australia $10,500 PBS Revestive Price
India ₹700,000 1mg Revestive Price

Top 5 Global Brands

  • Revestive (Shire Pharmaceuticals): The primary brand of teduglutide used for the treatment of short bowel syndrome.
  • Gattex (Takeda Pharmaceuticals): The US brand name for teduglutide used for the treatment of SBS in adults and children.
  • Norditropin (Novo Nordisk): A growth hormone used to treat various growth disorders including SBS.
  • Zorbtive (EMD Serono): A recombinant human growth hormone used for the treatment of SBS in adults.
  • Somatuline Depot (Ipsen): A somatostatin analog used for acromegaly and neuroendocrine tumors, sometimes utilized in managing SBS symptoms.
 
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