REVLIMID 10 MG 21 CAP

Revlimid 25 mg 21 Cap is a medication containing lenalidomide, used primarily for the treatment of certain cancers, including multiple myeloma and specific types of lymphoma. Revlimid is classified as an immunomodulatory agent, which alters the immune system and can help inhibit the growth of cancer cells.

How It Works

Mechanism of Action

Revlimid (lenalidomide) operates through several mechanisms to exert its therapeutic effects:

1. Immune System Modulation:
   • Lenalidomide enhances the immune system’s ability to recognize and attack cancer cells. It stimulates the production of cytokines that can help in fighting tumors and supports the activity of immune cells such as T cells and natural killer (NK) cells.
2. Anti-Angiogenic Effects:
   • It inhibits angiogenesis, the process by which new blood vessels form. This is important because tumors require a blood supply to grow and spread. By preventing new blood vessels from forming, lenalidomide helps to starve the tumor of essential nutrients and oxygen.
3. Direct Anti-Tumor Activity:
   • Lenalidomide directly affects cancer cells by inducing apoptosis (programmed cell death) and interfering with the tumor cell’s ability to proliferate.
4. Inhibition of Tumor Cell Adhesion:
   • It disrupts the interaction between tumor cells and the bone marrow environment, which is crucial for tumor growth and survival.

Side Effects

Common Side Effects

• Fatigue:
  • General tiredness or weakness is commonly reported.
• Diarrhea:
  • Gastrointestinal disturbances, including diarrhea.
• Nausea:
  • Feeling nauseous or having an upset stomach.
• Constipation:
  • Difficulty in bowel movements.
• Skin Rash:
  • Rashes or itching of the skin.

Serious Side Effects

• Blood Disorders:
  • Anemia, thrombocytopenia (low platelet count), and neutropenia (low white blood cells).
• Risk of Infections:
  • Increased susceptibility to infections due to immunosuppression.
• Liver Dysfunction:
  • Elevated liver enzymes or jaundice.
• Deep Vein Thrombosis (DVT) and Pulmonary Embolism:
  • Risk of blood clots.
• Birth Defects:
  • Highly teratogenic; can cause severe birth defects if taken during pregnancy.
• Allergic Reactions:
  • Severe reactions including anaphylaxis, though rare.

Indications

Revlimid is indicated for:

• Multiple Myeloma:
  • Used in combination with other drugs for the treatment of multiple myeloma.
• Myelodysplastic Syndromes (MDS):
  • Particularly in patients with deletion 5q cytogenetic abnormality.
• Follicular Lymphoma:
  • Used in cases of relapsed or refractory follicular lymphoma.
• Diffuse Large B-Cell Lymphoma:
  • For treatment of this type of lymphoma, often in combination with other therapies.

Contraindications

Revlimid should not be used in the following conditions:

• Pregnancy:
  • Contraindicated due to the risk of severe birth defects and fetal harm.
• Severe Liver Disease:
  • Not recommended for patients with severe liver impairment.
• Hypersensitivity:
  • Known hypersensitivity to lenalidomide or any component of the formulation.
• Severe Renal Impairment:
  • Dose adjustment required; avoid if renal function is severely impaired.
• Breastfeeding:
  • Should not be used while breastfeeding due to potential risk to the infant.

Price in Different Countries

Here is a table showing the approximate prices for Revlimid 25 mg in various countries, along with references:

Country	Price (Per 21 Capsules)	Reference
United States	$16,000 – $20,000	GoodRx
United Kingdom	£12,000 – £15,000	NHS UK
Canada	CAD $18,000 – $22,000	Health Canada
Australia	AUD $20,000 – $24,000	PBS Australia
India	₹1,00,000 – ₹1,20,000	Medlife

Top 5 Global Brands

1. Revlimid – Celgene Corporation:
   • The original and most well-known brand of lenalidomide used for cancer treatment.
2. Lenalidomide – Natco Pharma:
   • A generic version of Revlimid, providing similar therapeutic effects.
3. Lenalidomide – Mylan:
   • Offers a generic alternative to Revlimid.
4. Lenalidomide – Teva Pharmaceuticals:
   • Generic lenalidomide with the same efficacy.
5. Lenalidomide – Dr. Reddy’s Laboratories:
   • Another generic version of Revlimid, providing cost-effective treatment options.