Rinvoq Upadacitinib 15 mg Tablet

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Description

How it Works

Rinvoq (upadacitinib) is a Janus kinase (JAK) inhibitor used to treat various autoimmune conditions. JAK enzymes play a crucial role in the signaling pathway of several cytokines and growth factors that are important for hematopoiesis and immune function. By inhibiting JAK1, Rinvoq interferes with the JAK-STAT signaling pathway, which reduces the activity of the immune system that causes inflammation and damage in autoimmune diseases. This helps in reducing the symptoms and progression of diseases such as rheumatoid arthritis, psoriatic arthritis, and atopic dermatitis.

Side Effects

  • Upper respiratory tract infections
  • Nausea
  • Cough
  • Fever
  • Headache
  • Increased blood creatine phosphokinase
  • Elevated liver enzymes
  • Abdominal pain
  • Hyperlipidemia (high cholesterol levels)
  • Weight gain
  • Herpes zoster (shingles)
  • Thrombocytopenia (low platelet count)
  • Anemia
  • Fatigue

Indications

  • Moderate to severe rheumatoid arthritis in adults who have had an inadequate response or intolerance to methotrexate
  • Moderate to severe active psoriatic arthritis in adults
  • Moderate to severe active ankylosing spondylitis in adults
  • Moderate to severe atopic dermatitis in adults and pediatric patients 12 years and older
  • Moderate to severe ulcerative colitis in adults

Contraindications

  • Hypersensitivity to upadacitinib or any of its excipients
  • Active serious infections, including tuberculosis
  • Severe hepatic impairment
  • Pregnancy and breastfeeding (use with caution and only if clearly needed)
  • Concurrent use with other JAK inhibitors, biologic disease-modifying antirheumatic drugs (DMARDs), or potent immunosuppressants like azathioprine or cyclosporine

Price Comparison in Different Countries

Country Price (USD) Website
United States $5,500 GoodRx
Canada $4,800 PharmacyChecker
United Kingdom ?3,900 NHS
Australia AUD 7,000 PBS
India ?350,000 Medindia

Top 5 Global Brands

  1. Rinvoq (AbbVie)
  2. Xeljanz (Pfizer, JAK inhibitor)
  3. Olumiant (Eli Lilly, JAK inhibitor)
  4. Humira (AbbVie, TNF inhibitor)
  5. Enbrel (Amgen, TNF inhibitor)
 
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