ROFERON 3 MIO PRE. SYRINGE

Roferon 3 MIO Pre-filled Syringe is a pharmaceutical product containing interferon alfa-2a, a type of interferon used in the treatment of various cancers and viral infections. This medication is used in its pre-filled syringe form for ease of administration, often in the treatment of chronic conditions where precise and consistent dosing is necessary.

How It Works

Mechanism of Action

Roferon (interferon alfa-2a) functions through several mechanisms:

1. Immunomodulation:
   • Interferon alfa-2a enhances the immune system’s ability to recognize and destroy abnormal cells, including cancer cells. It increases the activity of immune cells such as T cells and natural killer (NK) cells.
2. Antiviral Effects:
   • It interferes with the replication of viruses by stimulating the production of antiviral proteins that inhibit viral replication within infected cells.
3. Direct Anti-Tumor Activity:
   • It has direct effects on tumor cells, including the induction of apoptosis (programmed cell death) and inhibition of tumor cell growth.
4. Regulation of Cell Growth:
   • It affects cellular processes, including the regulation of cell division and differentiation, which is crucial in cancer treatment.

Side Effects

Common Side Effects

• Flu-like Symptoms:
  • Fever, chills, muscle aches, and fatigue.
• Headache:
  • Persistent or severe headache.
• Nausea and Vomiting:
  • Gastrointestinal disturbances, including nausea and vomiting.
• Fatigue:
  • General tiredness or weakness.
• Injection Site Reactions:
  • Pain, redness, or swelling at the site of injection.

Serious Side Effects

• Hematological Issues:
  • Decreased blood cell counts such as anemia, leukopenia (low white blood cells), and thrombocytopenia (low platelet count).
• Mental Health Effects:
  • Depression, mood swings, or severe psychiatric symptoms.
• Liver Dysfunction:
  • Elevated liver enzymes, hepatitis, or jaundice.
• Autoimmune Disorders:
  • Potential development of autoimmune conditions due to immune system activation.
• Severe Allergic Reactions:
  • Anaphylaxis or severe allergic reactions, though rare.

Indications

Roferon is indicated for the treatment of:

• Chronic Hepatitis B:
  • A viral infection of the liver that requires long-term management.
• Chronic Hepatitis C:
  • A viral infection of the liver that can lead to serious liver conditions.
• Hairy Cell Leukemia:
  • A rare type of leukemia characterized by abnormal B cells.
• Non-Hodgkin’s Lymphoma:
  • A group of cancers that originate in the lymphatic system.
• Renal Cell Carcinoma:
  • A type of kidney cancer.

Contraindications

Roferon should not be used in the following conditions:

• Pregnancy:
  • Should not be used during pregnancy due to potential harm to the fetus.
• Severe Liver Disease:
  • Contraindicated in patients with severe liver impairment.
• Autoimmune Disorders:
  • Patients with certain autoimmune disorders may experience exacerbation of their condition.
• Severe Mental Health Issues:
  • Should be used with caution in patients with severe psychiatric disorders or a history of depression.
• Hypersensitivity:
  • Known hypersensitivity to interferon alfa-2a or any component of the formulation.

Price in Different Countries

Here is a table showing the approximate prices for Roferon 3 MIO in various countries, along with references:

Country	Price (Per Syringe)	Reference
United States	$2,000 – $2,500	GoodRx
United Kingdom	£1,500 – £2,000	NHS UK
Canada	CAD $2,200 – $2,800	Health Canada
Australia	AUD $2,500 – $3,000	PBS Australia
India	₹1,00,000 – ₹1,50,000	Medlife

Top 5 Global Brands

1. Roferon-A – Roche:
   • The original and well-known brand of interferon alfa-2a.
2. Intron A – Schering-Plough:
   • Another brand of interferon alfa-2b, which is similar to Roferon but with some formulation differences.
3. Pegasys – Roche:
   • A pegylated form of interferon alfa-2a, providing prolonged action compared to standard interferon.
4. PegIntron – Schering-Plough:
   • Pegylated interferon alfa-2b, used for similar indications as Roferon.
5. Alfaferon – United Biotech:
   • A brand offering interferon alfa-2b, used in various therapeutic settings.