Saphnelo anifrolumab 300gm/2ml injection

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Description

Saphnelo (anifrolumab) is a monoclonal antibody used for the treatment of moderate to severe systemic lupus erythematosus (SLE) in adult patients who are receiving standard therapy. Each injection contains 300mg of anifrolumab in 2mL of solution. Saphnelo works by targeting and inhibiting the type I interferon receptor, which is believed to play a role in the pathogenesis of lupus.

How It Works

Anifrolumab is a monoclonal antibody that binds to the type I interferon receptor, blocking the activity of type I interferons. Type I interferons are cytokines involved in the regulation of the immune system, and their overproduction is associated with the inflammatory processes seen in systemic lupus erythematosus. By inhibiting these interferons, anifrolumab helps to reduce inflammation and disease activity in patients with lupus.

Indications

  • Moderate to severe systemic lupus erythematosus (SLE) in adult patients receiving standard therapy

Contraindications

  • Hypersensitivity to anifrolumab or any component of the formulation
  • Severe active infections

Side Effects

  • Upper respiratory tract infections
  • Bronchitis
  • Infusion-related reactions
  • Herpes zoster
  • Cough
  • Nasopharyngitis
  • Headache
  • Diarrhea
  • Urinary tract infections

Price in Different Countries

Country Price (per 300mg/2mL injection) References
United States $5,000 GoodRx Saphnelo Price
United Kingdom £4,200 NHS Saphnelo Price
Canada $6,500 Canada Drugs Saphnelo Price
Australia $6,000 PBS Saphnelo Price
India ₹350,000 1mg Saphnelo Price

Top 5 Global Brands

  • Saphnelo (AstraZeneca): The original brand of anifrolumab, approved for the treatment of SLE.
  • Benlysta (GlaxoSmithKline): Another biologic therapy for lupus, targeting B-lymphocyte stimulator (BLyS).
  • Humira (AbbVie): A widely used monoclonal antibody for autoimmune conditions, targeting TNF-alpha.
  • Rituxan (Genentech/Biogen): A monoclonal antibody targeting CD20, used in various autoimmune diseases.
  • Enbrel (Amgen): A TNF inhibitor used in the treatment of autoimmune diseases like rheumatoid arthritis and psoriasis.
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