somatuline (Lanreotide) injection

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Description

How It Works

Lanreotide works by mimicking the action of somatostatin, a hormone that regulates the endocrine system and affects neurotransmission and cell proliferation. By binding to somatostatin receptors on the surface of cells, Lanreotide reduces the secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), which helps manage the symptoms of acromegaly. It also inhibits the secretion of several gastrointestinal hormones, thereby controlling the growth of certain tumors and managing symptoms of carcinoid syndrome.

Side Effects

  • Injection site pain or reaction
  • Gastrointestinal disturbances (e.g., diarrhea, abdominal pain, nausea)
  • Gallstones
  • Weight loss
  • Fatigue
  • Bradycardia (slow heart rate)
  • Hypoglycemia or hyperglycemia
  • Hair loss

Indications

  • Acromegaly in patients who have not responded to or are not candidates for surgery and/or radiotherapy
  • Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) to improve progression-free survival
  • Management of symptoms associated with carcinoid syndrome

Contraindications

  • Hypersensitivity to Lanreotide or any component of the formulation
  • Severe liver or kidney impairment without appropriate monitoring and dosage adjustment
  • Uncontrolled diabetes mellitus

Price Comparison in Different Countries

Country Price (per injection) Reference
Pakistan Approximately PKR 80,000 Dawaai Pakistan
United States USD 5,000 GoodRx
United Kingdom GBP 3,000 NHS UK
Canada CAD 4,500 Health Canada
Australia AUD 6,000 PBS Australia

Top 5 Global Brands

  1. Novartis
  2. Pfizer
  3. Sanofi
  4. Roche
  5. GlaxoSmithKline (GSK)

Conclusion

Somatuline Injection (Lanreotide) is an important therapeutic option for managing conditions like acromegaly, GEP-NETs, and carcinoid syndrome. By mimicking the action of somatostatin, it helps control hormone levels and inhibit tumor growth. Patients using Somatuline should be aware of potential side effects and contraindications, and discuss these with their healthcare provider. The cost of Somatuline varies significantly by country, reflecting differences in healthcare systems and pricing strategies. Patients should explore financial assistance programs and consult their healthcare providers to understand the best options available to them.  
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