Spinraza (Nusinersen) 12mg/5ml injection

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Description

Spinraza (nusinersen) is a prescription medication used to treat spinal muscular atrophy (SMA) in pediatric and adult patients. Each vial contains 12 mg of nusinersen in a 5 ml solution for intrathecal injection (injection into the spinal canal), designed to deliver the medication directly to the central nervous system.

How It Works

Nusinersen is an antisense oligonucleotide that targets and binds to a specific sequence of RNA, leading to increased production of survival motor neuron (SMN) protein. SMN protein is critical for the maintenance of motor neurons, and its deficiency is the underlying cause of SMA. By enhancing SMN protein levels, Spinraza helps improve motor function and slows the progression of SMA.

Side Effects

  • Lower respiratory infections
  • Constipation
  • Headache
  • Vomiting
  • Back pain
  • Post-lumbar puncture syndrome (headache, nausea, vomiting, dizziness)
  • Increased risk of bleeding and bruising (thrombocytopenia)

Indications

  • Treatment of spinal muscular atrophy (SMA) in pediatric and adult patients

Contraindications

  • Known hypersensitivity to nusinersen or any of its components

Price in Different Countries

Country Price (USD) Reference
United States $125,000 per injection GoodRx
Canada $100,000 per injection Canada Pharmacy
United Kingdom ?95,000 per injection UK Meds
Australia AUD 150,000 per injection Australia Pharmacy
India ?9,000,000 per injection India Meds

Top 5 Global Brands

  • Biogen – Manufacturer of Spinraza
  • Novartis
  • Roche
  • Pfizer
  • Sanofi
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