spravato (Esketamine) nasal spray 84 mg


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How Spravato Works

Spravato is a medication used for the treatment of treatment-resistant depression (TRD) and major depressive disorder (MDD) with suicidal ideation in adults. It contains esketamine, which is a form of ketamine, a dissociative anesthetic. The exact mechanism of how esketamine works to alleviate depression is not fully understood, but it is believed to involve modulation of glutamate, an important neurotransmitter in the brain. By acting on the glutamate system, esketamine helps to restore synaptic connections and improve mood regulation in individuals with depression.

Side Effects of Spravato

  • Disassociation (feeling disconnected from oneself or reality)
  • Dizziness
  • Sedation
  • Headache
  • Nausea
  • Increased blood pressure
  • Vomiting
  • Vertigo
  • Blurred vision
These side effects are typically mild to moderate in severity and may diminish with repeated doses. However, some individuals may experience more serious adverse reactions, so it’s essential to monitor for any unusual symptoms and consult a healthcare professional if needed.  

Indications for Spravato

  • Treatment-resistant depression (TRD) in adults
  • Major depressive disorder (MDD) with suicidal ideation in adults

Contraindications for Spravato

  • Hypersensitivity to esketamine or any component of the formulation
  • History of psychosis or psychotic disorder
  • Uncontrolled hypertension
  • Substance abuse or dependence, including alcohol
  • Recent use of monoamine oxidase inhibitors (MAOIs)

Price Comparison of Spravato in Different Countries

Country Price (per nasal spray) Reference
Pakistan PKR 8,000 medicalstore.com.pk
United States USD 590 US Pharmacy
United Kingdom GBP 450 UK Pharmacy
Canada CAD 700 Canadian Pharmacy
Australia AUD 800 Australian Pharmacy

Top 5 Global Brands of Depression Medications

  1. Spravato (Esketamine)
  2. Prozac (Fluoxetine)
  3. Zoloft (Sertraline)
  4. Lexapro (Escitalopram)
  5. Cymbalta (Duloxetine)
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