SPRYCEL 20 MG 60 TB

Sprycel (dasatinib) 20 mg (60 tablets) is a prescription medication used primarily in the treatment of certain types of cancer, particularly chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). Dasatinib is a tyrosine kinase inhibitor (TKI) that targets specific proteins involved in cancer cell growth and proliferation.

How It Works

Mechanism of Action

Sprycel (dasatinib) works by:

1. Inhibiting Tyrosine Kinases:
   • Dasatinib specifically inhibits the BCR-ABL tyrosine kinase, which is produced by the Philadelphia chromosome and is responsible for the uncontrolled growth of cancer cells in chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL).
2. Blocking Multiple Kinases:
   • In addition to BCR-ABL, dasatinib also inhibits several other tyrosine kinases involved in cell signaling pathways that regulate cancer cell growth, including Src family kinases, which contribute to cancer progression.
3. Preventing Cell Division:
   • By blocking these key signaling pathways, dasatinib interferes with the proliferation and survival of cancer cells, leading to their destruction and inhibiting tumor growth.

Side Effects

Common Side Effects

• Headache:
  • Mild to moderate headaches are common.
• Gastrointestinal Symptoms:
  • Nausea, diarrhea, and abdominal pain.
• Fatigue:
  • General tiredness and weakness.
• Skin Rash:
  • Rash or itching may occur.

Serious Side Effects

• Hematologic Toxicity:
  • Decrease in blood cell counts, including anemia, neutropenia (low white blood cells), and thrombocytopenia (low platelet counts).
• Pleural Effusion:
  • Accumulation of fluid around the lungs, which can cause breathing difficulties.
• Liver Dysfunction:
  • Elevated liver enzymes and potential liver damage.
• Bleeding:
  • Increased risk of bleeding or bruising.
• Heart Problems:
  • Potential for heart failure or arrhythmias.

Indications

Sprycel is indicated for:

• Chronic Myeloid Leukemia (CML):
  • For the treatment of adult and pediatric patients with Philadelphia chromosome-positive CML who are in the chronic phase, accelerated phase, or blast phase.
• Acute Lymphoblastic Leukemia (ALL):
  • For the treatment of adult and pediatric patients with Philadelphia chromosome-positive ALL.
• Other Indications:
  • May be used in certain cases of other hematologic malignancies if prescribed by a healthcare provider.

Contraindications

Sprycel should not be used in the following conditions:

• Hypersensitivity:
  • Known hypersensitivity to dasatinib or any of its components.
• Severe Liver Impairment:
  • Patients with severe liver impairment may need dose adjustments or alternative treatments.
• Pregnancy:
  • Should be avoided during pregnancy due to potential harm to the fetus. Effective contraception is recommended for women of childbearing potential.
• Severe Pulmonary Conditions:
  • Patients with severe pleural effusion or significant lung issues should avoid use or use with caution.

Price in Different Countries

Here is a table showing approximate prices for Sprycel 20 mg (60 tablets) in various countries, along with references:

Country	Price (Per Pack)	Reference
United States	$3,000 – $3,500	GoodRx
United Kingdom	£2,500 – £3,000	NHS UK
Canada	CAD $3,200 – $3,800	Health Canada
Australia	AUD $3,500 – $4,000	PBS Australia
India	₹2,00,000 – ₹2,50,000	Medlife

Top 5 Global Brands

1. Sprycel – Bristol-Myers Squibb:
   • The original and well-known brand of dasatinib.
2. Dasatinib Tablets – Various Manufacturers:
   • Generic versions of dasatinib, available under different brand names.
3. Dasanat – Various Manufacturers:
   • Another brand providing dasatinib, often as a generic option.
4. Dasigo – Various Manufacturers:
   • A generic form of dasatinib available in some markets.
5. Dasavix – Various Manufacturers:
   • Generic dasatinib under a different brand name.