Stelara (Ustekinumab) Injection

Stelara (ustekinumab) is a biologic medication used to treat various autoimmune conditions. It is an injectable drug that targets specific immune system proteins to reduce inflammation and manage symptoms associated with these conditions.

How It Works

Stelara is a monoclonal antibody that targets interleukin-12 (IL-12) and interleukin-23 (IL-23). These cytokines play a crucial role in the inflammatory processes of several autoimmune diseases.

Mechanism of Action:

1. Cytokine Inhibition: Stelara binds to the p40 subunit shared by IL-12 and IL-23, blocking their interaction with cell surface receptors.
2. Reduction of Inflammation: By inhibiting these cytokines, Stelara decreases the inflammatory response and modifies the immune system’s activity.
3. Symptom Relief: This leads to a reduction in the symptoms of autoimmune diseases such as psoriasis and Crohn’s disease.

Side Effects

Stelara is generally well-tolerated, but like all medications, it can cause side effects. These can vary from mild to severe.

Common Side Effects:

• Injection Site Reactions: Pain, redness, or swelling at the injection site.
• Headache: Mild to moderate headaches may occur.
• Upper Respiratory Infections: Such as sore throat or sinusitis.

Serious Side Effects:

• Infections: Increased risk of serious infections due to immune system suppression.
• Allergic Reactions: Rare but serious reactions including rash, itching, or swelling.
• Gastrointestinal Issues: Such as diarrhea or abdominal pain.

Indications

Stelara is indicated for the treatment of several autoimmune conditions.

Approved Indications:

1. Psoriasis: Moderate to severe plaque psoriasis in adults and children 6 years and older.
2. Psoriatic Arthritis: For the treatment of active psoriatic arthritis in adults.
3. Crohn’s Disease: Moderate to severe Crohn’s disease in adults who have had an inadequate response to conventional therapies.
4. Ulcerative Colitis: Moderate to severe ulcerative colitis in adults.

Contraindications

Certain conditions or treatments may contraindicate the use of Stelara due to potential risks or interactions.

Contraindications:

1. Hypersensitivity to Ustekinumab: Known allergy to ustekinumab or any component of the injection.
2. Active Infections: Patients with active, serious infections should avoid Stelara due to its immunosuppressive effects.
3. Live Vaccinations: Caution is advised when administering live vaccines during treatment.

Price in Different Countries

The cost of Stelara varies by country, reflecting different healthcare systems and pricing regulations. The following table provides approximate prices in different regions along with references for further information.

Country	Price (Per Dose)	Reference
United States	$5,000 – $6,000	GoodRx
United Kingdom	£3,800 – £4,500	NHS
Australia	AUD $6,500 – $7,500	PBS Australia
India	INR ₹75,000 – ₹85,000	1MG
Canada	CAD $5,500 – $6,500	Canada Pharmacy

Top 5 Global Brands

Here are the top brands in the market for biologics and treatments for autoimmune conditions:

1. Johnson & Johnson

• Manufacturer of Stelara (ustekinumab), a leading biologic for autoimmune diseases.

2. AbbVie

• Known for Humira (adalimumab), another prominent biologic for autoimmune disorders.

3. Roche

• Produces Actemra (tocilizumab), used for rheumatoid arthritis and other inflammatory conditions.

4. Amgen

• Offers Enbrel (etanercept), which targets tumor necrosis factor (TNF) and is used for various inflammatory diseases.

5. Bristol-Myers Squibb

• Known for Orencia (abatacept), used in the treatment of rheumatoid arthritis and other autoimmune diseases.