tafinlar (dabrafenib) 75 mg 120 capsule

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Description

How It Works

Tafinlar (generic name dabrafenib) is a kinase inhibitor that works by targeting and inhibiting the activity of mutated forms of the BRAF protein. BRAF mutations are commonly found in certain types of cancer, including melanoma and non-small cell lung cancer (NSCLC). By inhibiting the mutated BRAF protein, Tafinlar helps to slow down or stop the growth of cancer cells.

Side Effects

  • Fever
  • Fatigue
  • Nausea
  • Diarrhea
  • Skin rash

Indications

  • Tafinlar is indicated for the treatment of unresectable or metastatic melanoma with BRAF V600E mutation, as detected by an FDA-approved test.
  • It is also used in combination with trametinib for the treatment of BRAF V600 mutation-positive advanced non-small cell lung cancer (NSCLC).

Contraindications

  • Severe hypersensitivity reaction to dabrafenib
  • Severe renal impairment
  • Severe hepatic impairment

Price Comparison in Different Countries

Country Price (per unit) References
United States $10,000 GoodRx
United Kingdom ?7,000 NHS
Australia AUD 12,000 PBS Australia
Canada CAD 14,000 Canadian Cancer Society
Germany ?9,000 Apotheken Umschau

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