takhzyro (lanadelumab-flyo injection)


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How It Works

Takhzyro (lanadelumab-flyo) is a monoclonal antibody that works by inhibiting plasma kallikrein, an enzyme that plays a crucial role in the pathway that leads to the production of bradykinin. Bradykinin is a peptide that causes blood vessels to dilate and become leaky, leading to the symptoms of hereditary angioedema (HAE). By blocking plasma kallikrein, Takhzyro reduces the frequency and severity of HAE attacks.

List of Side Effects

  • Injection site reactions
  • Upper respiratory infections
  • Headache
  • Dizziness
  • Rash
  • Muscle pain
  • Diarrhea
  • Fever
  • Abdominal pain
  • Nausea

List of Indications

  • Prophylaxis to prevent attacks of hereditary angioedema (HAE) in patients 12 years and older

List of Contraindications

  • Severe hypersensitivity to lanadelumab-flyo or any of the excipients in Takhzyro

Price in Different Countries

Country Price (USD) Reference Website
United States $24,000 GoodRx
United Kingdom ?18,000 NICE BNF
Canada $30,000 CAD CanadaDrugs.com
Australia $35,000 AUD PBS Australia
India ?1,800,000 INR 1mg
Pakistan ? 3,800,000 PKR Dawaai.pk

Top 5 Global Brands

  1. Takhzyro (Lanadelumab-flyo) – Takeda
  2. Haegarda (C1 Esterase Inhibitor Subcutaneous [Human]) – CSL Behring
  3. Firazyr (Icatibant) – Shire (part of Takeda)
  4. Berinert (C1 Esterase Inhibitor [Human]) – CSL Behring
  5. Ruconest (Recombinant C1 Inhibitor) – Pharming Group
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