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  • Tarpeyo (budesonide) 4mg 120 Capsule

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    Description

    Tarpeyo (budesonide) 4mg is a modified-release oral corticosteroid capsule specifically designed to treat adults with primary immunoglobulin A nephropathy (IgAN), also known as Berger’s disease, an immune condition that can damage kidney filters. Tarpeyo delivers targeted therapy directly to the gut-associated lymphoid tissue, where immune overactivity in IgAN begins, effectively helping to reduce protein leakage from the kidneys and manage disease progression.

    How Tarpeyo Works

    Tarpeyo contains budesonide, a corticosteroid that provides targeted anti-inflammatory action. When taken orally, Tarpeyo’s unique release system allows budesonide to be gradually absorbed in the ileum and colon, where it acts to reduce local inflammation. By targeting the gut-associated lymphoid tissue (GALT), Tarpeyo helps to lower IgA immune complex formation and deposition in the kidneys. This can significantly reduce kidney inflammation and proteinuria, thereby helping to protect kidney function in IgA nephropathy patients.

    Indications

    Tarpeyo is specifically indicated for:
    • Primary IgA Nephropathy (IgAN): It is used in patients with proteinuria (high protein levels in urine) who are at risk of kidney function decline.

    Side Effects

    Common side effects of Tarpeyo include:
    • Headache
    • Elevated blood pressure
    • Acne
    • Upper respiratory infections
    • Weight gain
    • Gastrointestinal discomfort
    Serious side effects can include:
    • Adrenal insufficiency
    • Increased risk of infections
    • Osteoporosis (bone weakening)
    • Glaucoma or cataracts
    • Elevated blood sugar levels

    Contraindications

    Tarpeyo should not be used in the following cases:
    • Allergy: Patients with known hypersensitivity to budesonide or any ingredients in the formulation.
    • Systemic Fungal Infections: Not recommended for patients with systemic fungal infections.
    • Severe Hepatic Impairment: Tarpeyo is not recommended in patients with severely impaired liver function.
    • Active Tuberculosis: Avoid in patients with untreated tuberculosis.

    Price of Tarpeyo in Different Countries

    The following table provides approximate pricing for Tarpeyo across different countries. Prices may vary based on pharmacy, insurance coverage, and local pricing regulations.
    Country Price (per month supply) Source
    United States $7,000 – $9,000 GoodRx
    Canada CAD 8,000 – CAD 9,500 DrugBank Canada
    United Kingdom £6,000 – £8,000 NHS UK
    Australia AUD 10,000 – AUD 12,000 PBS Australia
    Germany €7,000 – €9,000 Medikamentenpreis Germany

    Top 5 Global Brands of Corticosteroids for IgA Nephropathy

    • Tarpeyo (budesonide) – Specifically approved for IgA nephropathy with targeted delivery to reduce kidney inflammation.
    • Entocort (budesonide) – Used for inflammatory bowel disease but also used off-label for IgA nephropathy in some cases.
    • Prednisone – A commonly used corticosteroid that has a broad anti-inflammatory effect in various autoimmune conditions.
    • CellCept (mycophenolate mofetil) – An immunosuppressant that is often used in combination with corticosteroids for IgA nephropathy.
    • Prograf (tacrolimus) – Used off-label for IgA nephropathy, helping in reducing immune responses that damage kidney tissues.
     
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    Tarpeyo (budesonide) 4mg 120 Capsule
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