Tecfidera (Dimethyl Fumarate) 240 mg 56 tablet imported

Tecfidera (Dimethyl Fumarate) 240 mg (56 tablets) is a prescription medication used primarily in the treatment of multiple sclerosis (MS). Dimethyl fumarate is known for its role in managing relapsing forms of MS, a chronic disease affecting the central nervous system.

How It Works

Mechanism of Action

Tecfidera contains dimethyl fumarate, which works through several mechanisms to benefit patients with multiple sclerosis:

1. Activation of Nrf2 Pathway:
   • Dimethyl fumarate activates the Nrf2 (nuclear factor erythroid 2-related factor 2) pathway, which helps protect cells from oxidative stress and inflammation. This pathway is crucial in reducing the neuroinflammation associated with MS.
2. Reduction of Inflammation:
   • The medication has anti-inflammatory properties that help reduce the inflammatory responses in the central nervous system, leading to fewer MS flare-ups and potentially slowing disease progression.
3. Neuroprotection:
   • Tecfidera may also promote neuroprotection by decreasing oxidative damage and preserving neuronal integrity, which can help in maintaining cognitive function and reducing disability over time.

Side Effects

Common Side Effects

• Flushing:
  • A common side effect where patients experience redness and warmth in the skin, especially on the face.
• Gastrointestinal Issues:
  • Includes symptoms like nausea, diarrhea, abdominal pain, and indigestion.
• Headache:
  • Patients may experience mild to moderate headaches.

Serious Side Effects

• Lymphopenia:
  • A decrease in white blood cells, which can increase the risk of infections.
• Progressive Multifocal Leukoencephalopathy (PML):
  • A rare but serious brain infection that can cause severe disability or be life-threatening.
• Liver Problems:
  • Elevated liver enzymes, which may indicate liver damage or dysfunction.
• Hypersensitivity Reactions:
  • Allergic reactions including rash, itching, and swelling.

Indications

Tecfidera is indicated for:

• Relapsing Forms of Multiple Sclerosis:
  • Used to treat adults with relapsing forms of MS, including relapsing-remitting MS and active secondary progressive MS. It helps reduce the frequency of relapses and slows the progression of disability.

Contraindications

Tecfidera should not be used in the following conditions:

• Hypersensitivity:
  • Known hypersensitivity to dimethyl fumarate or any of the product’s components.
• Severe Liver Impairment:
  • Caution is advised in patients with severe liver dysfunction.
• Pregnancy:
  • It is recommended to avoid using Tecfidera during pregnancy unless clearly needed. Effective contraception is advised for women of childbearing potential.
• Severe Renal Impairment:
  • Use with caution in patients with severe kidney problems.

Price in Different Countries

Here is a table showing approximate prices for Tecfidera 240 mg (56 tablets) in various countries, along with references:

Country	Price (Per Pack)	Reference
United States	$6,000 – $6,500	GoodRx
United Kingdom	£4,500 – £5,000	NHS UK
Canada	CAD $6,500 – $7,000	Health Canada
Australia	AUD $7,000 – $7,500	PBS Australia
India	₹4,00,000 – ₹4,50,000	Medlife

Top 5 Global Brands

1. Tecfidera – Biogen:
   • The original and well-known brand of dimethyl fumarate.
2. Dimethyl Fumarate Tablets – Various Manufacturers:
   • Generic versions of dimethyl fumarate available under different names.
3. Dimifumar – Various Manufacturers:
   • A brand providing dimethyl fumarate, often as a generic option.
4. Fumarix – Various Manufacturers:
   • A generic form of dimethyl fumarate available in some markets.
5. Diemfort – Various Manufacturers:
   • Another generic version of dimethyl fumarate.