Tremfya Guselkumab 100mg Injection


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How it Works

Tremfya, with the active ingredient guselkumab, is a monoclonal antibody used in the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy. Guselkumab selectively binds to the p19 subunit of interleukin-23 (IL-23) and inhibits its interaction with the IL-23 receptor. By blocking IL-23, guselkumab prevents the activation of Th17 cells and the subsequent release of inflammatory cytokines such as IL-17 and IL-22. This reduces inflammation and leads to improvement in psoriatic skin lesions.

Side Effects

  • Upper respiratory tract infections
  • Headache
  • Injection site reactions (pain, erythema, bruising, itching)
  • Nausea
  • Fatigue
  • Diarrhea
  • Back pain
  • Urinary tract infections
  • Arthralgia (joint pain)
  • Fungal skin infections
  • Oral herpes


  • Moderate to severe plaque psoriasis in adults who are candidates for systemic therapy


  • Hypersensitivity to guselkumab or any of its excipients
  • Active tuberculosis
  • Active infection requiring systemic therapy

Price Comparison in Different Countries

Country Price (USD) Website
United States $8,000 per injection GoodRx
Canada $7,000 per injection PharmacyChecker
United Kingdom ?6,000 per injection NHS
Australia AUD 10,000 per injection PBS
Germany ?7,500 per injection Aponeo

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