tyrvaya (varenicline solution) nasal spray

Tyrvaya (varenicline solution) is a nasal spray indicated for treating the symptoms of dry eye disease in adults. It offers an alternative delivery route through nasal administration, which stimulates the body’s natural tear production. Tyrvaya is a recent innovation in dry eye therapy and is typically prescribed to patients whose dry eye condition has not improved with standard artificial tear drops or other eye-related treatments.

How Tyrvaya Works

Varenicline, the active ingredient in Tyrvaya, acts as a partial agonist of the nicotinic acetylcholine receptors. When administered as a nasal spray, it targets the trigeminal nerve within the nasal passages. By activating receptors in the nasal pathways, Tyrvaya promotes stimulation of the parasympathetic pathway, which ultimately leads to an increase in natural tear production. This mechanism is unique to Tyrvaya, distinguishing it from topical eye drops that directly apply tears or lubricants to the eye surface. Nasal stimulation of tear production provides a full, natural tear that helps with lubrication and ocular surface health.

Indications

Tyrvaya is indicated for use in the following conditions:

• Dry Eye Disease: For patients experiencing symptoms of dry eye disease who have not found relief with other treatments.
• Chronic Ocular Dryness: May be prescribed for patients with ongoing, persistent symptoms of dryness or irritation due to insufficient tear production.

Side Effects

Common side effects of Tyrvaya include:

• Sneezing
• Nasal irritation or congestion
• Unpleasant taste in the mouth
• Runny nose
• Cough

Less common but more serious side effects may include:

• Severe nasal discomfort or inflammation
• Headache
• In rare cases, sensitivity reactions in the nasal passages

Contraindications

Tyrvaya is contraindicated in the following cases:

• Allergy to Varenicline: Contraindicated in patients with a known hypersensitivity to varenicline or any other ingredients in Tyrvaya.
• Chronic Nasal Infections or Conditions: Should not be used in individuals with active, ongoing nasal infections or conditions that affect the nasal passages.
• Pregnancy and Lactation: Not recommended for use during pregnancy or breastfeeding, as the effects on the fetus or infant are unknown.
• Respiratory Conditions: Use with caution in individuals with respiratory conditions that may be aggravated by nasal sprays.

Price of Tyrvaya in Different Countries

The table below provides approximate pricing for Tyrvaya (varenicline solution) nasal spray in various countries. Prices may vary depending on the pharmacy, insurance coverage, and local regulations.

Country	Price (per bottle)	Source
United States	$300 – $350	GoodRx
Canada	CAD 320 – CAD 360	PharmacyChecker
United Kingdom	£260 – £290	NHS UK
Australia	AUD 420 – AUD 450	PBS Australia
India	INR 22,000 – INR 25,000	1mg India

Top 5 Global Brands for Varenicline and Dry Eye Disease Treatments

• Tyrvaya (Oyster Point Pharma) – The first and only nasal spray for dry eye disease based on varenicline solution.
• Restasis (Allergan) – An established treatment that promotes natural tear production in patients with chronic dry eye.
• Xiidra (Novartis) – An eye drop therapy for dry eye that targets the inflammation associated with dry eye disease.
• Systane (Alcon) – A popular over-the-counter artificial tear product for temporary dry eye relief.
• Refresh (Allergan) – A range of artificial tear products designed for dry eye relief and ocular surface support.