Ultomiris ravulizumab 300 mg Injection


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How it Works

Ultomiris, with the active ingredient ravulizumab, is a monoclonal antibody used in the treatment of paroxysmal nocturnal hemoglobinuria (PNH) in adults. Ravulizumab targets complement component C5 and inhibits its cleavage into C5a and C5b. By inhibiting C5 cleavage, ravulizumab prevents the generation of the terminal complement complex C5b-9, which is responsible for cell lysis in PNH. This action reduces hemolysis and the associated symptoms of PNH.

Side Effects

  • Headache
  • Fatigue
  • Upper respiratory tract infections
  • Nausea
  • Viral infections
  • Diarrhea
  • Abdominal pain
  • Back pain
  • Injection site reactions (pain, erythema, bruising)
  • Hypertension (high blood pressure)
  • Dizziness
  • Insomnia


  • Paroxysmal nocturnal hemoglobinuria (PNH) in adults


  • Hypersensitivity to ravulizumab or any of its excipients
  • Meningococcal infection or a history of meningococcal infection
  • Patients not currently vaccinated against meningococcal infection

Price Comparison in Different Countries

Country Price (USD) Website
United States $19,000 per injection GoodRx
Canada $18,000 per injection PharmacyChecker
United Kingdom ?16,000 per injection NHS
Australia AUD 28,000 per injection PBS
Germany ?20,000 per injection Aponeo

Top 5 Global Brands

  1. Ultomiris (Alexion Pharmaceuticals)
  2. Soliris (Alexion Pharmaceuticals)
  3. Ravulizumab (Alexion Pharmaceuticals)
  4. Elzonris (Takeda Pharmaceuticals)
  5. Cablivi (Ablynx, a Sanofi Company)
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