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  • Velsipity (etrasimod) 2mg 30 tablets

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    Description

    Velsipity (etrasimod) is a once-daily oral medication containing 2 mg of etrasimod, a selective sphingosine 1-phosphate (S1P) receptor modulator used for the treatment of moderate to severe ulcerative colitis. Etrasimod works by modulating immune cell trafficking, thereby helping to manage inflammation in the gastrointestinal tract associated with ulcerative colitis.

    How Velsipity Works

    Velsipity’s active ingredient, etrasimod, is an S1P receptor modulator that works by selectively targeting the S1P1 receptor. This mechanism helps reduce the migration of lymphocytes (white blood cells) from the lymph nodes to areas of inflammation, particularly in the intestines. By limiting the number of immune cells reaching the gastrointestinal tract, Velsipity helps to reduce inflammation, alleviating symptoms such as abdominal pain, diarrhea, and bleeding in patients with ulcerative colitis. This targeted approach also minimizes systemic immunosuppression, thereby reducing the risk of adverse effects.

    Indications

    Velsipity is primarily indicated for:
    • Ulcerative Colitis (UC): Approved for the treatment of adults with moderate to severe ulcerative colitis who may not have responded adequately to other treatments.

    Side Effects

    Common side effects of Velsipity include:
    • Headache
    • Abdominal pain
    • Nausea
    • Increased liver enzymes
    • Respiratory tract infections
    Serious side effects can include:
    • Bradycardia (slow heart rate)
    • Increased risk of infections
    • Elevated liver enzyme levels
    • Macular edema (swelling in the retina)

    Contraindications

    Velsipity should not be used in the following cases:
    • Severe Cardiovascular Conditions: Patients with recent heart attack, stroke, or other severe heart conditions.
    • Uncontrolled Infections: Patients with active or uncontrolled infections.
    • Severe Liver Impairment: Not recommended for patients with severe hepatic impairment.
    • Hypersensitivity: Any known allergy to etrasimod or components in the formulation.

    Price of Velsipity in Different Countries

    The following table provides approximate pricing for Velsipity across different countries. Prices may vary based on pharmacy, insurance coverage, and local pricing regulations.
    Country Price (per month supply) Source
    United States $5,000 – $6,500 GoodRx
    Canada CAD 6,000 – CAD 7,200 DrugBank Canada
    United Kingdom £4,500 – £5,500 NHS UK
    Australia AUD 7,000 – AUD 8,500 PBS Australia
    Germany €5,000 – €6,000 Medikamentenpreis Germany

    Top 5 Global Brands for Ulcerative Colitis Treatment

    • Velsipity (etrasimod) – A targeted S1P receptor modulator for treating moderate to severe ulcerative colitis.
    • Entyvio (vedolizumab) – A monoclonal antibody used for Crohn’s disease and ulcerative colitis, focusing on gut-specific inflammation.
    • Humira (adalimumab) – An anti-TNF biologic commonly used in moderate to severe ulcerative colitis.
    • Stelara (ustekinumab) – An IL-12 and IL-23 inhibitor effective in treating inflammatory bowel diseases.
    • Xeljanz (tofacitinib) – An oral Janus kinase (JAK) inhibitor used for moderate to severe ulcerative colitis.
     
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    Velsipity (etrasimod) 2mg 30 tablets
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