Verzenio (Abemaciclib) 150 mg Tablets

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Description

How it Works

Verzenio (abemaciclib) is a targeted therapy used in the treatment of certain types of breast cancer. It works by inhibiting cyclin-dependent kinases 4 and 6 (CDK4/6). These kinases are enzymes that, when overactive, contribute to the proliferation of cancer cells. By inhibiting CDK4/6, Verzenio interferes with the cell cycle, specifically preventing the transition from the G1 phase to the S phase, which is crucial for cell division. This results in the slowing down or stopping of cancer cell growth and replication, thereby controlling the progression of the disease.

Side Effects

  • Diarrhea
  • Neutropenia (low white blood cell count)
  • Nausea
  • Fatigue
  • Abdominal pain
  • Infections
  • Low red blood cell count (anemia)
  • Decreased appetite
  • Vomiting
  • Headache
  • Hair thinning or loss
  • Thrombocytopenia (low platelet count)
  • Increased liver enzymes

Indications

  • Hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced or metastatic breast cancer
  • In combination with an aromatase inhibitor as initial endocrine-based therapy for postmenopausal women
  • In combination with fulvestrant in patients with disease progression following endocrine therapy
  • As monotherapy for adult patients with HR+, HER2- advanced or metastatic breast cancer with disease progression following endocrine therapy and prior chemotherapy in the metastatic setting

Contraindications

  • Hypersensitivity to abemaciclib or any of its excipients
  • Severe hepatic impairment
  • Pregnancy and breastfeeding (use with caution and only if clearly needed)
  • Concurrent use with strong CYP3A inhibitors

Price Comparison in Different Countries

Country Price (USD) Website
United States $13,000 GoodRx
Canada $11,000 PharmacyChecker
United Kingdom ?10,000 NHS
Australia AUD 15,000 PBS
India ?950,000 Medindia

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