Vraylar (cariprazine) 3mg per capsule

How it Works

Vraylar, with the active ingredient cariprazine, is an atypical antipsychotic medication used in the treatment of schizophrenia and bipolar disorder. Cariprazine works by acting as a partial agonist at dopamine D₂ and serotonin 5-HT_1A receptors, and as an antagonist at serotonin 5-HT_2A receptors. This unique pharmacological profile modulates dopaminergic and serotonergic neurotransmission in the brain, leading to improvements in psychotic symptoms associated with schizophrenia and mood symptoms associated with bipolar disorder.

Side Effects

• Extrapyramidal symptoms (e.g., tremor, rigidity, dystonia)
• Weight gain
• Akathisia (restlessness)
• Sedation
• Dizziness
• Orthostatic hypotension (low blood pressure upon standing)
• Dyslipidemia (abnormal levels of lipids in the blood)
• Increased blood sugar levels
• Insomnia
• Constipation
• Nausea
• Vomiting

Indications

• Schizophrenia
• Bipolar I disorder (manic or mixed episodes)

Contraindications

• Hypersensitivity to cariprazine or any of its excipients
• Patients with a history of neuroleptic malignant syndrome (NMS)
• Patients with a history of tardive dyskinesia
• Patients with severe hepatic impairment
• Concomitant use with strong CYP3A4 inhibitors or inducers
• Patients with a history of QT prolongation or arrhythmias

Price Comparison in Different Countries

Country	Price (USD)	Website
United States	$800 per month	GoodRx
Canada	$700 per month	PharmacyChecker
United Kingdom	?600 per month	NHS
Australia	AUD 1000 per month	PBS
Germany	?700 per month	Aponeo

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1. Vraylar (Allergan)
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