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Description
Xalkori (crizotinib) is a medication developed by Pfizer, primarily used for the treatment of non-small cell lung cancer (NSCLC) that is caused by a defect in the ALK (anaplastic lymphoma kinase) gene. It works as a protein kinase inhibitor, blocking an enzyme crucial for cancer cell growth and proliferation.
- Effective Treatment: Xalkori has been shown to be effective in targeting and treating ALK-positive NSCLC, improving progression-free survival rates.
- Oral Administration: It is available in capsule form, making it easier to administer compared to intravenous treatments.
- FDA Approved: It has received FDA approval, ensuring it has undergone rigorous testing for safety and efficacy.
- Patient Assistance Programs: Various programs are available to help patients afford the medication, such as Pfizer’s Oncology Together Co-Pay Savings Program
- High Cost: The medication is very expensive, with prices for a 60-capsule supply ranging from around $5,579 to over $9,300 depending on the supplier .
- Side Effects: Common side effects include vision problems, nausea, diarrhea, and fatigue. More severe effects can include liver problems and interstitial lung disease.
- Specific Genetic Marker Required: It is only effective for patients with the ALK gene mutation, limiting its use to a specific subset of lung cancer patients.
- Potential for Drug Interactions: Xalkori can interact with other medications, necessitating careful management and consultation with healthcare providers.
- U.S. Prices: The cost in the U.S. is about $5,579.33 for a 60-capsule supply (Drugs.com).
- International Prices: Prices can vary significantly internationally. For example, in some countries, the cost per capsule can be around $155.21, bringing a 60-capsule supply to about $9,312.84 (PharmacyChecker.com).
- India: In India, the price may be lower, but specifics on the 200 mg dosage were not detailed. Typically, medications sourced from India can be significantly cheaper.