Xipere (triamcinolone acetonide injectable suspension)

Xipere is an injectable suspension containing triamcinolone acetonide, a corticosteroid specifically formulated to be delivered via suprachoroidal injection to treat macular edema associated with uveitis. It targets inflammation and swelling in the back of the eye, providing a local, sustained-release of corticosteroid directly to the affected area. Xipere is generally prescribed to patients whose macular edema has not improved with other treatments, particularly in cases related to non-infectious uveitis.

How Xipere Works

Triamcinolone acetonide, the active component of Xipere, is a corticosteroid that reduces inflammation by inhibiting the release of pro-inflammatory cytokines and mediators. Delivered through a suprachoroidal injection, Xipere is injected into the space between the sclera and choroid, allowing targeted therapy directly to the back of the eye. This targeted delivery reduces systemic side effects and helps to concentrate the medication where it is needed, reducing inflammation, lowering swelling, and improving vision in patients with macular edema associated with uveitis.

Indications

Xipere is primarily indicated for use in:

• Macular Edema associated with Uveitis: Indicated for the treatment of macular edema in patients with non-infectious uveitis that affects the posterior segment of the eye.
• Chronic Uveitis-related Swelling: Helps reduce inflammation and swelling associated with uveitis that has not responded to other treatments.

Side Effects

Potential side effects of Xipere include:

• Increased intraocular pressure (IOP)
• Cataract formation
• Eye pain or discomfort at the injection site
• Blurred vision
• Increased risk of ocular infection
• Floaters or visual disturbances
• Redness or irritation in the eye

Serious side effects, though less common, may include:

• Severe eye infection or inflammation
• Significant increases in IOP
• Retinal detachment

Contraindications

Xipere should not be used in the following cases:

• Active Ocular Infections: Contraindicated in patients with active eye infections, including viral, bacterial, or fungal infections.
• Glaucoma: Should not be used in individuals with glaucoma, due to the potential for increased intraocular pressure.
• Allergy to Triamcinolone Acetonide: Not recommended for patients with a known hypersensitivity to triamcinolone acetonide or any of the other ingredients in Xipere.
• Systemic Infection: Contraindicated in individuals with active, untreated systemic infections.

Price of Xipere in Different Countries

The table below provides approximate pricing for Xipere (triamcinolone acetonide injectable suspension) in various countries. Prices may vary depending on the pharmacy, insurance coverage, and local regulations.

Country	Price (per vial)	Source
United States	$1,500 – $1,600	GoodRx
Canada	CAD 1,400 – CAD 1,500	PharmacyChecker
United Kingdom	£1,200 – £1,300	NHS UK
Australia	AUD 2,200 – AUD 2,300	PBS Australia
India	INR 90,000 – INR 95,000	1mg India

Top 5 Global Brands for Triamcinolone Acetonide and Ocular Corticosteroids

• Xipere (Clearside Biomedical) – A unique suprachoroidal injectable corticosteroid specifically for macular edema associated with uveitis.
• Triesence (Alcon) – An injectable form of triamcinolone used for various eye conditions requiring corticosteroid therapy.
• Kenalog (Bristol-Myers Squibb) – A widely used corticosteroid injection, commonly used off-label for eye conditions.
• Ozurdex (Allergan) – A dexamethasone intravitreal implant for treating macular edema and uveitis.
• Retisert (Bausch & Lomb) – An implant providing sustained release of corticosteroids for chronic non-infectious uveitis.