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  • Zirabev 25 mg/ml concentrate for solution for infusion

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    Description

    Zirabev is a biosimilar to Avastin (bevacizumab), an anti-angiogenic drug used in the treatment of various cancers. It contains bevacizumab, which is a monoclonal antibody that inhibits vascular endothelial growth factor (VEGF). By targeting VEGF, Zirabev helps to prevent the growth of blood vessels that supply tumors, thereby inhibiting tumor growth. Each vial contains 25 mg/ml of bevacizumab for intravenous infusion.

    How It Works

    Zirabev works by binding to and neutralizing VEGF, a protein that stimulates the formation of blood vessels (angiogenesis). VEGF is overexpressed in many tumors and contributes to tumor growth by providing the necessary blood supply. By inhibiting VEGF, Zirabev reduces the formation of new blood vessels, thereby starving the tumor of nutrients and oxygen needed for its growth and survival. This action helps to control tumor growth and spread.

    Side Effects

    • Hypertension (high blood pressure)
    • Fatigue
    • Diarrhea
    • Abdominal pain
    • Nausea and vomiting
    • Proteinuria (protein in urine)
    • Hemorrhage
    • Thromboembolic events (blood clots)
    • Wound healing complications
    • Gastrointestinal perforation
    • Leukopenia (low white blood cell count)
    • Neutropenia (low neutrophil count)

    Indications

    • Metastatic colorectal cancer
    • Non-small cell lung cancer
    • Glioblastoma
    • Renal cell carcinoma
    • Cervical cancer
    • Ovarian cancer
    • Fallopian tube cancer
    • Primary peritoneal cancer

    Contraindications

    • Hypersensitivity to bevacizumab or any of its components
    • Recent surgery or major injury
    • Untreated central nervous system (CNS) metastases
    • Pregnancy
    • Severe hypertension that cannot be controlled with medication

    Price in Different Countries

     
    Country Price (per vial) References
    United States $900 GoodRx Zirabev Price
    United Kingdom £700 NHS Zirabev Price
    Canada $850 Canada Drugs Zirabev Price
    Australia $880 PBS Zirabev Price
    India ₹65,000 1mg Zirabev Price

    Top 5 Global Brands

    • Zirabev (Pfizer): A biosimilar to Avastin, used to treat various cancers by inhibiting angiogenesis.
    • Avastin (Genentech/Roche): The original bevacizumab product, widely used for treating several types of cancer.
    • Mvasi (Amgen): Another biosimilar to Avastin, used in oncology for similar indications.
    • Aybintio (Samsung Bioepis): A bevacizumab biosimilar approved for various cancer treatments.
    • Equidacent (Biocon): A recent entry in the bevacizumab biosimilar market, offering a cost-effective alternative.
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    Zirabev 25 mg/ml concentrate for solution for infusion
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