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Description
How Cerezyme Works
Cerezyme is an enzyme replacement therapy used in the treatment of Gaucher disease, a rare genetic disorder characterized by the deficiency of an enzyme called glucocerebrosidase. This enzyme deficiency leads to the accumulation of a fatty substance called glucocerebroside in various organs, particularly the spleen, liver, and bone marrow. Cerezyme works by supplying the missing enzyme glucocerebrosidase to the body, which helps to break down and remove the accumulated glucocerebroside from cells. By reducing the buildup of glucocerebroside, Cerezyme helps to alleviate symptoms and complications associated with Gaucher disease.Side Effects of Cerezyme
- Headache
- Nausea
- Abdominal pain
- Fatigue
- Allergic reactions (rash, itching, swelling)
- Injection site reactions (redness, swelling, pain)
- Flu-like symptoms
- Joint pain
- Bone pain
Indications for Cerezyme
- Gaucher disease type 1 (non-neuronopathic)
Contraindications for Cerezyme
- Hypersensitivity to imiglucerase (the active ingredient in Cerezyme)
- Acute complications of Gaucher disease, such as severe bone pain, fractures, or thrombocytopenia
- Pregnancy (unless the potential benefits outweigh the risks)
Price Comparison of Cerezyme in Different Countries
Country | Price (per vial) | Reference |
---|---|---|
Pakistan | PKR 100,000 | medicalstore.com.pk Pakistan |
United States | USD 10,000 | Sanofi US |
United Kingdom | GBP 7,000 | Sanofi UK |
Canada | CAD 12,000 | Sanofi Canada |
Australia | AUD 15,000 | Sanofi Australia |
Top 5 Global Brands of Enzyme Replacement Therapies for Gaucher Disease
- Cerezyme (Imiglucerase)
- Vpriv (Velaglucerase alfa)
- Elelyso (Taliglucerase alfa)
- Lumizyme (Alglucosidase alfa)
- Cerdelga (Eliglustat)