Ixazomib (Ninlaro)

Ixazomib (Ninlaro) is an oral medication that belongs to a class of drugs called proteasome inhibitors. Proteasome inhibitors work by blocking the action of proteasomes, which are complex structures that break down proteins in cells. By blocking proteasomes, ixazomib can cause the buildup of abnormal proteins in multiple myeloma cells, leading to their death. Ixazomib is approved by the FDA for the treatment of patients with multiple myeloma who have received at least one prior therapy. It is used in combination with lenalidomide (Revlimid) and dexamethasone, two other drugs that have different mechanisms of action against multiple myeloma. This combination is known as the NINLARO regimen.

The Benefits of the NINLARO Regimen for Relapsed Multiple Myeloma

The NINLARO regimen has been shown to improve the time people are able to live with their multiple myeloma without it getting worse by nearly 6 months compared to the lenalidomide and dexamethasone combination alone. This is called progression-free survival (PFS). The median PFS for the NINLARO regimen was 20.6 months versus 14.7 months for the lenalidomide and dexamethasone combination. The NINLARO regimen also has a favorable safety profile, with side effects similar to those of the lenalidomide and dexamethasone combination. The most common side effects of the NINLARO regimen include low platelet counts, diarrhea, constipation, nausea, vomiting, nerve problems, and swelling. These side effects can be managed with dose adjustments, supportive care, and medication as needed. Another benefit of the NINLARO regimen is that it is an all-oral treatment option, which means that patients do not need to visit a clinic or hospital for injections or infusions. This can help patients maintain an active lifestyle and reduce the burden of treatment.

How to Take the NINLARO Regimen

The NINLARO regimen consists of three drugs: ixazomib (Ninlaro), lenalidomide (Revlimid), and dexamethasone. The treatment cycle is 28 days long and repeats until disease progression or unacceptable toxicity.

• Ixazomib is taken once a week on days 1, 8, and 15 of each cycle. The usual dose is 4 mg, but it may be reduced or interrupted depending on side effects or laboratory results.
• Lenalidomide is taken once a day on days 1 to 21 of each cycle. The usual dose is 25 mg, but it may be reduced or interrupted depending on side effects or laboratory results.
• Dexamethasone is taken once a week on days 1, 8, 15, and 22 of each cycle. The usual dose is 40 mg, but it may be reduced or interrupted depending on side effects or laboratory results.

It is important to follow the instructions of your healthcare provider on how to take the NINLARO regimen. You should also keep track of your medication schedule and any side effects you experience. You should have regular blood tests and check-ups to monitor your response and safety.

The Price of Ixazomib (Ninlaro) in Different Countries

The price of ixazomib (Ninlaro) may vary depending on the country where you buy it. Here is a table that shows the approximate price of ixazomib in some countries, based on online sources as of October 2023. The prices are in US dollars and do not include taxes, shipping fees, or discounts.

Price of Ixazomib (Ninlaro) in Different Countries

Country	Price per capsule (4 mg)	Source
USA	$1,000	Drugs.com
Canada	$800	Canada Drugs Direct
UK	$700	Pharmacy2U
Australia	$600	Chemist Warehouse
India	$300	Medixo Centre

The Top 5 Global Brands of Ixazomib (Ninlaro)

Ixazomib (Ninlaro) is a brand name of the generic drug ixazomib, which is manufactured by Takeda Oncology. However, there are also other brands of ixazomib that are available in different countries. Here are the top 5 global brands of ixazomib, based on online sources as of October 2023.

1. Ninlaro: This is the original brand name of ixazomib, which is approved in the USA, Canada, Europe, Australia, Japan, and many other countries. It is marketed by Takeda Oncology.
2. Ninlarix: This is a brand name of ixazomib that is approved in India. It is marketed by Cipla.
3. Nixal: This is a brand name of ixazomib that is approved in China. It is marketed by Jiangsu Hengrui Medicine.
4. Nixam: This is a brand name of ixazomib that is approved in Russia. It is marketed by Pharmstandard.
5. Nixar: This is a brand name of ixazomib that is approved in Brazil. It is marketed by Eurofarma.

If you are interested in buying ixazomib (Ninlaro) or any other brand of ixazomib, you should consult your healthcare provider and check the availability and legality of the product in your country. You should also compare the prices and quality of different sources and look for reliable and reputable online pharmacies.