• 0 items in quote

    No products in the Quote Basket.

  • AFINITOR 5 MG 30 TB

    Quantity

    Get Price

    Get it to United States within 10 working days with standard delivery.

    Fast delivery to United States

    Easy Returns & Exchanges

    Ask About This Product

    Condition : New

    0

    From UAE

    To United States

    in 5-10 days

    Description

    AFINITOR (Everolimus) is an oral medication used primarily for the treatment of various cancers and non-cancerous tumors. It belongs to a class of drugs known as mTOR inhibitors. By inhibiting the mTOR (mammalian target of rapamycin) pathway, AFINITOR plays a crucial role in regulating cell growth, proliferation, and survival. It is used to treat advanced kidney cancer, certain types of breast cancer, pancreatic neuroendocrine tumors, and other conditions where excessive cell growth is a concern. AFINITOR is available in tablet form and is taken once daily, with the dosage and treatment duration depending on the specific condition and patient factors.

    How AFINITOR Works

    Mechanism of Action:

    1. mTOR Inhibition:
      • AFINITOR works by inhibiting the mTOR protein, a critical regulator of cell growth and proliferation. mTOR is involved in several cellular processes, including protein synthesis, autophagy, and metabolism.
    2. Blocking Tumor Cell Growth:
      • By inhibiting mTOR, AFINITOR disrupts the signaling pathways that promote tumor cell growth, division, and survival. This action slows down or stops the proliferation of cancer cells.
    3. Anti-Angiogenic Effects:
      • AFINITOR also has anti-angiogenic properties, meaning it inhibits the formation of new blood vessels that tumors need to grow and spread. This helps to starve the tumor of oxygen and nutrients, further inhibiting its growth.
    4. Modulation of Immune Response:
      • Everolimus also affects immune cells, which can be beneficial in conditions like organ transplantation and certain types of non-cancerous tumors. This immunosuppressive effect is utilized in preventing rejection of transplanted organs.
    5. Reduction of Tumor-Associated Inflammation:
      • By reducing the production of inflammatory cytokines, AFINITOR can help alleviate symptoms associated with tumor growth, such as pain and swelling.

    Combined Effect:

    The combined effect of mTOR inhibition and anti-angiogenic activity results in decreased tumor cell proliferation, reduced metastasis, and overall improved outcomes in patients with cancer and other mTOR pathway-related diseases.

    Side Effects

    AFINITOR can cause a range of side effects, some of which can be severe. Side effects vary depending on the condition being treated, dosage, and individual patient factors.

    Common Side Effects:

    • Mouth Ulcers (Stomatitis): Painful sores inside the mouth that can affect eating and speaking.
    • Rash: Skin reactions including rash, itching, and dryness.
    • Fatigue: Persistent tiredness that affects daily activities.
    • Diarrhea: Frequent loose or watery stools.
    • Infections: Increased susceptibility to bacterial, viral, and fungal infections.
    • Loss of Appetite: Reduced desire to eat, leading to weight loss.
    • Nausea and Vomiting: Gastrointestinal disturbances that can be mild to moderate.
    • Cough and Shortness of Breath: Respiratory symptoms that may affect breathing.
    • Elevated Blood Sugar Levels: Hyperglycemia, which may require management.

    Rare but Serious Side Effects:

    • Pneumonitis: Inflammation of lung tissue, which can cause serious breathing difficulties.
    • Kidney Failure: Decreased kidney function that may necessitate medical intervention.
    • Liver Dysfunction: Elevated liver enzymes indicating possible liver damage.
    • Severe Infections: Such as sepsis or pneumonia, requiring immediate medical attention.
    • Severe Allergic Reactions: Including anaphylaxis, characterized by difficulty breathing, hives, and swelling.

    Indications

    AFINITOR is approved for the treatment of several cancerous and non-cancerous conditions, reflecting its broad utility in managing diseases driven by abnormal cell growth.

    Approved Indications:

    • Advanced Renal Cell Carcinoma (RCC): For patients with advanced kidney cancer who have failed previous treatments.
    • Hormone Receptor-Positive, HER2-Negative Breast Cancer: In combination with exemestane in postmenopausal women with advanced disease.
    • Pancreatic Neuroendocrine Tumors (PNET): For advanced PNET that are not surgically removable.
    • Tuberous Sclerosis Complex (TSC)-Associated Renal Angiomyolipoma: For patients who do not require immediate surgery.
    • TSC-Associated Subependymal Giant Cell Astrocytoma (SEGA): In patients who are not candidates for curative surgical resection.

    Contraindications

    AFINITOR may not be suitable for everyone, and certain medical conditions or risk factors may prevent its use.

    Contraindications:

    • Hypersensitivity: Known hypersensitivity to everolimus, sirolimus, or any of the excipients in AFINITOR.
    • Severe Liver Impairment: Due to the increased risk of adverse effects and drug accumulation.
    • Pregnancy: AFINITOR can harm an unborn baby, so it should not be used during pregnancy.
    • Active Infections: Patients with active, serious infections such as tuberculosis should not use AFINITOR until the infection is controlled.
    • Uncontrolled Hyperlipidemia: Elevated cholesterol or triglyceride levels that are not managed.

    Price in Different Countries

    The cost of AFINITOR can vary significantly based on location, healthcare systems, and market conditions.
    Country Price (Per 30 Tablets) Reference
    United States $10,000 – $12,000 GoodRx
    United Kingdom £6,500 – £8,000 NHS UK
    Canada CAD $9,000 – $11,500 Health Canada
    Australia AUD $13,000 – $15,000 PBS Australia
    India ₹700,000 – ₹850,000 1mg

    Top 5 Global Brands

    AFINITOR is marketed under the Novartis brand, but similar drugs or mTOR inhibitors are also available from other manufacturers.

    1. AFINITOR (Everolimus)Novartis

    • A well-established mTOR inhibitor widely used for various cancer treatments and other conditions involving abnormal cell growth.

    2. Zortress (Everolimus)Novartis

    • Primarily used for preventing organ rejection in kidney transplant patients, Zortress shares the same active ingredient as AFINITOR.

    3. Votubia (Everolimus)Novartis

    • Marketed in the European Union, specifically used for treating TSC-related conditions.

    4. Rapamune (Sirolimus)Pfizer

    • Another mTOR inhibitor used primarily for transplant rejection but with some off-label cancer applications.

    5. Torisel (Temsirolimus)Pfizer

    • Similar to everolimus, Torisel is used for advanced renal cell carcinoma but differs in administration (IV).
    Shopping Cart
    AFINITOR 5 MG 30 TB
    Get Price