AROMASIN 25 MG 30 DRJ

AROMASIN (Exemestane) is an oral medication used in the treatment of breast cancer. It is formulated as 25 mg tablets and is typically prescribed to postmenopausal women. Aromasin is classified as an aromatase inhibitor, a type of medication that reduces estrogen levels in the body.

How AROMASIN Works

Mechanism of Action

1. Aromatase Inhibition:
   • Exemestane, the active ingredient in Aromasin, works by inhibiting the aromatase enzyme. Aromatase is responsible for converting androgens into estrogen in postmenopausal women. By blocking this enzyme, Aromasin significantly lowers estrogen levels.
2. Reduced Estrogen Levels:
   • Lower estrogen levels help to slow down or stop the growth of estrogen-dependent breast cancer cells. This is particularly effective in treating hormone receptor-positive breast cancers.
3. Prevention of Cancer Recurrence:
   • Aromasin is used both as an adjuvant therapy to prevent the recurrence of breast cancer after initial treatment and as a treatment for metastatic breast cancer.

Side Effects

Common Side Effects

• Hot Flashes:
  • Patients may experience hot flashes as a result of reduced estrogen levels.
• Fatigue:
  • General tiredness and weakness are common among users.
• Joint Pain:
  • Joint pain or arthralgia is frequently reported.
• Nausea:
  • Some individuals may experience nausea.
• Sweating:
  • Increased sweating, particularly night sweats, can occur.

Serious Side Effects

• Bone Density Loss:
  • Aromasin can lead to decreased bone density, increasing the risk of osteoporosis and fractures.
• Cardiovascular Issues:
  • There may be an increased risk of cardiovascular problems, including heart attacks.
• Liver Toxicity:
  • Liver enzyme abnormalities and potential liver damage may occur.
• Allergic Reactions:
  • Severe allergic reactions, including rash, itching, and swelling, are possible.

Indications

AROMASIN is indicated for:

• Early Stage Hormone Receptor-Positive Breast Cancer:
  • Used in postmenopausal women who have completed 2-3 years of treatment with tamoxifen and are being switched to Aromasin.
• Metastatic Breast Cancer:
  • Prescribed for postmenopausal women with advanced breast cancer that is hormone receptor-positive.
• Cancer Prevention:
  • May be used to reduce the risk of developing breast cancer in women at high risk.

Contraindications

AROMASIN should not be used in certain conditions:

• Hypersensitivity:
  • Known hypersensitivity to exemestane or any components of the formulation.
• Pregnancy and Lactation:
  • Not recommended during pregnancy or breastfeeding due to potential harm to the fetus or infant.
• Severe Liver Impairment:
  • Contraindicated in patients with severe liver dysfunction due to the risk of exacerbated liver toxicity.
• Pre-Menopausal Women:
  • Not intended for use in pre-menopausal women as it is ineffective in this population.
• Bone Density Issues:
  • Caution is advised in patients with severe osteoporosis or significant bone density loss.

Price in Different Countries

The cost of AROMASIN can vary significantly depending on the country and pharmacy. Below is a table with approximate prices and references for further details.

Country	Price (Per 25 mg/30 Tablets)	Reference
United States	$1,500 – $2,000	GoodRx
United Kingdom	£1,200 – £1,500	NHS UK
Canada	CAD $1,800 – $2,300	Canada Pharmacy
Australia	AUD $2,500 – $3,000	PBS Australia
India	₹20,000 – ₹25,000	1mg

Top 5 Global Brands

While Aromasin is a prominent brand, several other brands and generics are available for exemestane.

1. Aromasin (Exemestane) – Pfizer

• The original and most well-known brand of exemestane.

2. Exemestane Teva – Teva Pharmaceuticals

• A reputable generic version of exemestane.

3. Exemestane Mylan – Mylan Pharmaceuticals

• Another reliable generic option for exemestane.

4. Exemestane Accord – Accord Healthcare

• A widely used generic alternative.

5. Exemestane Sandoz – Sandoz

• A cost-effective version of exemestane provided by Sandoz.