AVONEX 30 MCG/0.5 ML INJ PEN

AVONEX (Interferon beta-1a) is a prescription medication used primarily for the treatment of multiple sclerosis (MS). It comes in a 30 mcg/0.5 mL injection pen, designed for ease of use. Avonex is an injectable medication administered once a week and is specifically indicated for relapsing forms of MS.

How AVONEX Works

Mechanism of Action

1. Interferon Beta-1a:
   • Avonex contains interferon beta-1a, a synthetic protein that mimics a naturally occurring protein in the body known as interferon beta. Interferons are involved in the immune response and play a role in regulating the immune system.
2. Modulation of Immune Response:
   • Interferon beta-1a works by modifying the immune system’s activity. It helps to reduce the frequency and severity of MS relapses by inhibiting the immune system’s attack on the central nervous system (CNS).
3. Reduction of Inflammation:
   • The drug reduces inflammation in the CNS by suppressing the production of pro-inflammatory cytokines and enhancing the production of anti-inflammatory cytokines.
4. Protection of Nerve Cells:
   • Avonex helps protect nerve cells from damage caused by the immune system’s attacks, thereby slowing disease progression.

Side Effects

Common Side Effects

• Flu-like Symptoms:
  • Fever, chills, and muscle aches are frequently reported, particularly after the first few doses.
• Fatigue:
  • Patients may experience general tiredness and weakness.
• Injection Site Reactions:
  • Pain, redness, or swelling at the injection site.
• Headache:
  • Some individuals report headaches following administration.

Serious Side Effects

• Liver Dysfunction:
  • Possible liver enzyme abnormalities and liver damage.
• Depression:
  • Can cause or exacerbate depressive symptoms. Monitoring for mood changes is recommended.
• Severe Allergic Reactions:
  • Symptoms such as rash, itching, swelling, severe dizziness, or trouble breathing.
• Blood Disorders:
  • May affect blood cell counts, leading to anemia, leucopenia, or thrombocytopenia.

Indications

AVONEX is indicated for:

• Relapsing Forms of Multiple Sclerosis:
  • Used to treat patients with relapsing forms of MS, including relapsing-remitting MS and secondary progressive MS with relapses.
• Reduction of MS Relapses:
  • Aims to reduce the frequency and severity of MS relapses.
• Disease Progression:
  • Helps in slowing the progression of disability associated with MS.

Contraindications

AVONEX should not be used in certain conditions:

• Hypersensitivity:
  • Known hypersensitivity to interferon beta-1a or any component of the formulation.
• Severe Liver Disease:
  • Contraindicated in patients with severe liver dysfunction due to the risk of exacerbated liver issues.
• Severe Depression:
  • Should be used with caution in individuals with a history of severe depression or suicidal ideation.
• Pregnancy and Breastfeeding:
  • Not recommended for use during pregnancy or breastfeeding due to potential risks to the fetus or infant.

Price in Different Countries

The price of AVONEX can vary significantly depending on the country and pharmacy. Below is a table with approximate prices and references for further details.

Country	Price (Per 30 mcg/0.5 mL Injection Pen)	Reference
United States	$6,000 – $7,000	GoodRx
United Kingdom	£4,500 – £5,000	NHS UK
Canada	CAD $7,000 – $8,000	Canada Pharmacy
Australia	AUD $9,000 – $10,000	PBS Australia
India	₹50,000 – ₹60,000	1mg

Top 5 Global Brands

AVONEX is a well-known brand for interferon beta-1a. While there are no direct equivalents, several brands and generics for interferon beta-1a and similar drugs are available globally.

1. Avonex (Interferon beta-1a) – Biogen

• The original and most recognized brand for interferon beta-1a.

2. Rebif (Interferon beta-1a) – Merck Serono

• Another brand of interferon beta-1a, used in similar indications.

3. Betaseron (Interferon beta-1b) – Bayer

• Contains interferon beta-1b, a related but distinct product used for MS.

4. Extavia (Interferon beta-1b) – Novartis

• A brand of interferon beta-1b, similar to Betaseron, with equivalent indications.

5. Plegridy (Peginterferon beta-1a) – Biogen

• A pegylated form of interferon beta-1a, offering extended dosing intervals.