Cabometyx (cabozantinib) 60mg tablet

How It Works

Cabozantinib is a tyrosine kinase inhibitor (TKI). It works by blocking the action of enzymes called tyrosine kinases. These enzymes are involved in the signaling pathways that regulate cell division and growth. By inhibiting these enzymes, Cabometyx can slow down or stop the growth of cancer cells, thereby helping to control the spread of the disease.

Side Effects

• Diarrhea
• Fatigue
• Nausea
• Decreased appetite
• Weight loss
• Vomiting
• Constipation
• Hypertension
• Hand-foot syndrome (redness, pain, and swelling of hands and feet)
• Increased liver enzymes
• Stomatitis (inflammation of the mouth and lips)

Indications

• Advanced renal cell carcinoma (RCC)
• Hepatocellular carcinoma (HCC) in patients who have previously been treated with sorafenib

Contraindications

• Severe hypersensitivity to cabozantinib or any of its excipients
• Pregnancy and breastfeeding

Price Comparison in Different Countries

Country	Price (per 60mg tablet)	Reference
Pakistan	Approximately PKR 120,000	medicalstore.com.pk Pakistan
United States	USD 500	GoodRx
United Kingdom	GBP 400	NHS UK
Canada	CAD 650	Health Canada
Australia	AUD 700	PBS Australia

Top 5 Global Pharmaceutical Brands

1. Pfizer
2. Novartis
3. Roche
4. Sanofi
5. GlaxoSmithKline (GSK)

Conclusion

Cabometyx (cabozantinib) is a significant advancement in the treatment of advanced renal cell carcinoma and hepatocellular carcinoma. By inhibiting tyrosine kinases, it helps manage the growth and spread of cancer cells. Patients should be aware of the possible side effects and contraindications, and consult their healthcare provider for personalized advice. The cost of Cabometyx can vary significantly by country, reflecting different healthcare policies and market conditions. Patients are encouraged to explore all available resources, including financial assistance programs, to manage the cost of their treatment effectively.