Cerezyme 400u/10ml 1 vial

How Cerezyme Works

Cerezyme is an enzyme replacement therapy used in the treatment of Gaucher disease, a rare genetic disorder characterized by the deficiency of an enzyme called glucocerebrosidase. This enzyme deficiency leads to the accumulation of a fatty substance called glucocerebroside in various organs, particularly the spleen, liver, and bone marrow. Cerezyme works by supplying the missing enzyme glucocerebrosidase to the body, which helps to break down and remove the accumulated glucocerebroside from cells. By reducing the buildup of glucocerebroside, Cerezyme helps to alleviate symptoms and complications associated with Gaucher disease.

Side Effects of Cerezyme

• Headache
• Nausea
• Abdominal pain
• Fatigue
• Allergic reactions (rash, itching, swelling)
• Injection site reactions (redness, swelling, pain)
• Flu-like symptoms
• Joint pain
• Bone pain

These side effects may vary in severity and frequency depending on individual factors and may require medical attention.

Indications for Cerezyme

• Gaucher disease type 1 (non-neuronopathic)

Contraindications for Cerezyme

• Hypersensitivity to imiglucerase (the active ingredient in Cerezyme)
• Acute complications of Gaucher disease, such as severe bone pain, fractures, or thrombocytopenia
• Pregnancy (unless the potential benefits outweigh the risks)

Price Comparison of Cerezyme in Different Countries

Country	Price (per vial)	Reference
Pakistan	PKR 100,000	medicalstore.com.pk Pakistan
United States	USD 10,000	Sanofi US
United Kingdom	GBP 7,000	Sanofi UK
Canada	CAD 12,000	Sanofi Canada
Australia	AUD 15,000	Sanofi Australia

 

Top 5 Global Brands of Enzyme Replacement Therapies for Gaucher Disease

1. Cerezyme (Imiglucerase)
2. Vpriv (Velaglucerase alfa)
3. Elelyso (Taliglucerase alfa)
4. Lumizyme (Alglucosidase alfa)
5. Cerdelga (Eliglustat)