Cerezyme 400u/10ml 1 vial


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How Cerezyme Works

Cerezyme is an enzyme replacement therapy used in the treatment of Gaucher disease, a rare genetic disorder characterized by the deficiency of an enzyme called glucocerebrosidase. This enzyme deficiency leads to the accumulation of a fatty substance called glucocerebroside in various organs, particularly the spleen, liver, and bone marrow. Cerezyme works by supplying the missing enzyme glucocerebrosidase to the body, which helps to break down and remove the accumulated glucocerebroside from cells. By reducing the buildup of glucocerebroside, Cerezyme helps to alleviate symptoms and complications associated with Gaucher disease.

Side Effects of Cerezyme

  • Headache
  • Nausea
  • Abdominal pain
  • Fatigue
  • Allergic reactions (rash, itching, swelling)
  • Injection site reactions (redness, swelling, pain)
  • Flu-like symptoms
  • Joint pain
  • Bone pain
These side effects may vary in severity and frequency depending on individual factors and may require medical attention.

Indications for Cerezyme

  • Gaucher disease type 1 (non-neuronopathic)

Contraindications for Cerezyme

  • Hypersensitivity to imiglucerase (the active ingredient in Cerezyme)
  • Acute complications of Gaucher disease, such as severe bone pain, fractures, or thrombocytopenia
  • Pregnancy (unless the potential benefits outweigh the risks)

Price Comparison of Cerezyme in Different Countries

Country Price (per vial) Reference
Pakistan PKR 100,000 medicalstore.com.pk Pakistan
United States USD 10,000 Sanofi US
United Kingdom GBP 7,000 Sanofi UK
Canada CAD 12,000 Sanofi Canada
Australia AUD 15,000 Sanofi Australia

Top 5 Global Brands of Enzyme Replacement Therapies for Gaucher Disease

  1. Cerezyme (Imiglucerase)
  2. Vpriv (Velaglucerase alfa)
  3. Elelyso (Taliglucerase alfa)
  4. Lumizyme (Alglucosidase alfa)
  5. Cerdelga (Eliglustat)
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