Praluent (alirocumab)150 mg solution for injection in pre-filled pen

How It Works

Praluent works by inhibiting a protein called proprotein convertase subtilisin/kexin type 9 (PCSK9). PCSK9 binds to low-density lipoprotein receptors (LDLR) on liver cells and promotes their degradation. These receptors are responsible for removing LDL cholesterol (“bad” cholesterol) from the blood. By inhibiting PCSK9, Praluent increases the number of LDLR available to clear LDL cholesterol from the blood, thus lowering the overall cholesterol levels.

Side Effects

• Injection site reactions (redness, itching, swelling)
• Nasopharyngitis (common cold)
• Flu-like symptoms
• Upper respiratory tract infections
• Muscle pain
• Back pain
• Allergic reactions
• Increased liver enzymes

Indications

• Primary hyperlipidemia (including heterozygous familial hypercholesterolemia) in adults who require additional lowering of LDL cholesterol
• Clinical atherosclerotic cardiovascular disease (to reduce the risk of myocardial infarction, stroke, and unstable angina requiring hospitalization)

Contraindications

• Hypersensitivity to alirocumab or any of the excipients in the formulation

Price Comparison in Different Countries

Country	Price (per pre-filled pen)	Reference
Pakistan	Approximately PKR 70,000	medicalstore.com.pk Pakistan
United States	USD 500	GoodRx
United Kingdom	GBP 350	NHS UK
Canada	CAD 650	Health Canada
Australia	AUD 700	PBS Australia

Top 5 Global Brands

1. Pfizer
2. Novartis
3. Sanofi
4. Roche
5. GlaxoSmithKline (GSK)

Conclusion

Praluent (alirocumab) is a crucial medication for managing high cholesterol levels in patients who require additional LDL cholesterol reduction. By inhibiting PCSK9, Praluent enhances the liver’s ability to clear LDL cholesterol from the blood, thereby lowering overall cholesterol levels. Patients should be aware of potential side effects and contraindications, and consult their healthcare provider for personalized advice. The cost of Praluent varies across different countries, reflecting variations in healthcare systems and pricing policies. Exploring financial assistance programs and discussing options with healthcare providers can help manage the cost of treatment effectively.